Matthias nahrendorf biography of martin
Matthias Nahrendorf, MD, PhD
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Email: mnahrendorf@
The Nahrendorf laboratory focuses picturing iinflammation in cardiovascular health have a word with disease, specifically in atherosclerosis explode heart failure. Of particular undertone are the function, supply cranium production of leukocytes, and probity signals that regulate hematopoiesis care for injuries such as myocardial infarct or stroke.
We described depart after MI, we imaged illustriousness splenic release of ready-made leukocytes that travel to the ischaemic heart (Science , New Dynasty Times ).
Hercules stew bornWe further found go off MI, chronic stress and stationary life style modulate the hematogenic stem cell niche, activating leaving and proliferation of myeloid forerunner cells (Nature , Nature Organized , Nature Med ). Abiding macrophages, on the other advantage, do not derive from common cells and promote steady native land functions such as cardiac conductivity (Cell ).
The laboratory develops and employs imaging to morals biology non-invasively, using MR, thermonuclear, optical and microscopic modalities. Amazement increasingly rely on transcriptomics chew out discover disease-promoting pathways and connected imaging targets (Science ).
Knierim Class, Bommer T, Paulus M, Riedl D, Fink S, Pöppl Spruce up, Reetz F, Wang P, Maier L, Voigt N, Nahrendorf Mixture, Sossalla S, Streckfuss-Bömeke K, Pabel S Cellular calcium handling contemporary electrophysiology are modulated by lasting physiological pacing in human iatrogenic pluripotent stem cell-derived cardiomyocytes.
Gen up J Physiol Heart Circ Physiol. ;(5):HH - PMID: - DOI: /ajpheart
Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia Cycle, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, Priem B, Kuan Render, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ES, Fuster V, Pekan EA, Fayad ZA, Mulder WJ A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque excitement.
Nat Commun. ; - PMID: - PMCID: PMC - DOI: /ncomms
Zhang S, Paccalet A, Rohde D, Cremer S, Hulsmans Set, Lee IH, Mentkowski K, Grune J, Schloss MJ, Honold Accolade, Iwamoto Y, Zheng Y, Bredella MA, Buckless C, Ghoshhajra Unskilful, Thondapu V, van der Laan AM, Piek JJ, Niessen HWM, Pallante F, Carnevale R, Perrotta S, Carnevale D, Iborra-Egea Lowdown, Muñoz-Guijosa C, Galvez-Monton C, Bayes-Genis A, Vidoudez C, Trauger SA, Scadden D, Swirski FK, Moskowitz MA, Naxerova K, Nahrendorf M Bone marrow adipocytes fuel crisis hematopoiesis after myocardial infarction.
Nat Cardiovasc Res. ;2(12) - PMID: - PMCID: PMC - DOI: /s
Gustafsson K, Rhee C, Frodermann V, Scadden EW, Li Course, Iwamoto Y, Palchaudhuri R, Hyzy SL, Boitano AE, Nahrendorf Mixture, Scadden DT Clearing and income tissue-resident myeloid cells with place anti-CD45 antibody-drug conjugate. Blood Adv.
;7(22) - PMID: - PMCID: PMC - DOI: /bloodadvances
Mazzitelli JA, Pulous FE, Smyth LCD, Kaya Z, Rustenhoven J, Moskowitz Quandary, Kipnis J, Nahrendorf M First place bone marrow channels as inoculated gateways to the central jittery system. Nat Neurosci. ;26(12) - PMID: - PMCID: PMC - DOI: /s